ESPE Abstracts

Background: Premature adrenarche is associated with overweight and insulin resistance, but the associations of serum dehydroepiandrosterone sulphate (DHEAS) concentration with other cardiometabolic risk factors are uncertain.Objective and hypotheses: We studied whether cardiometabolic risk factors and their clustering differ between children with higher and lower serum DHEAS concentration.Method: We studied 432 healthy children (20...

The physiology of adrenarche, i.e. the development of the zona reticularis of the adrenal cortex, is mostly unknow. Some genes of steroidogenic enzymes need to be down- (HSD3B2) while others upregulated (e.g. CYB5) to enhance androgen production in zona reticularis, but it is not known how this is regulated. Micro RNAs (miRNAs) are small non-coding RNAs that can affect gene expression at posttranscriptional level. We hypothesized that miRNAs might be involved in regulating adr...